All runes are perm and will not disappear.
Some gameplay tips:
Rune is a small piece of stone engraved with mysterious hieroglyphics that can be placed in socketed equipment. The difference between a rune and other items is that it not only a rune provides its own magical properties, but also allows for more powerful comprehensive properties when several runes are inserted in a certain order.
Runes can be used to make crafted items.