Cube all 3 parts in Hell Act 5 to create a Red Portal to Uber Tristram where you'll fight 3 Uber Bosses at once for the Hellfire Charm and Standard of Heroes.

Be prepared. This is extremely difficult.

Some gameplay tips:

Uber Izual at Furnace of Pain drops Mephisto's Brain. The challenge is moderate. Uber Izual is not difficult to fight. The real challenge comes from the knights that might accompany him.

[D2R Non-Ladder] Baal's Eye
$0.35

[D2R Non-Ladder] Diablo's Horn
$0.35

[D2R Non-Ladder] 7% Magic Find Good Luck Small Charm - Anya's Special Deals
$0.15

[D2R Non-Ladder] Key of Destruction
$0.15

[D2R Non-Ladder] #15 Hel Rune
$0.05

[D2R Non-Ladder] Key of Terror
$0.15

[D2R Non-Ladder] Charged Essence of Hatred
$0.15

[D2R Non-Ladder] String of Ears - Anya's Special Deal
$0.25

[D2R Non-Ladder] Angelic Wings
$0.45

[D2R Non-Ladder] #28 Lo Rune
$0.19

[D2R Non-Ladder] Magefist - Anya's Special Deal
$0.25

[D2R Non-Ladder] #1 El Rune
$0.05